Type the page number(s) where each item is reported in the boxes in the right-hand column, then save your copy as a PDF or Word (.docx) file. “Save as PDF” opens your browser’s print dialog: choose Save as PDF as the destination. Your entries stay in this browser until you clear them.
| Section / Topic | No | SPIRIT 2025 checklist item description | Reported on page no.type page no. in the boxes below |
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*We strongly recommend reading this checklist in conjunction with the SPIRIT 2025 Explanation and Elaboration and the SPIRIT 2025 Expanded Checklist for important clarifications on all the items. We also recommend reading relevant SPIRIT extensions. See www.consort-spirit.org
Citation: Chan A-W, Boutron I, Hopewell S, Moher D, Schulz KF, et al. SPIRIT 2025 statement: updated guideline for protocols of randomised trials. BMJ 2025;389:e081477. https://dx.doi.org/10.1136/bmj-2024-081477
© 2025 Chan A-W et al. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.